Researchers in Finland in the first week of July 2013 discovered that
by giving a very large dose of famotidine (200 mg daily), it is
possible to affect the histamine system in the brain. Famotidine was
used for the treatment of heartburn since the 1980s, but at regular
dosing, famotidine almost does not enter the brain at all, since the
brain is protected by the blood-brain barrier. By increasing the dosage
five-fold the drug is able to enter the brain and affect the histamine
system.
The team of researchers led by Professor Jesper Jesper Ekelund
observed that after one week the symptoms of people having schizophrenia
started to decrease and after four weeks of treatment the symptoms
decreased significantly.
Thirty people having schizophrenia participated in the study. The
patients had been on sickness pension for at least five years. They were
randomly divided into two groups, one which received famotidine and one
which received placebo.
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